Abstract
The effects of a variety of local anesthetics on mitochondrial activities were measured. The latter included oxygen consumption, K+ and Ca++ transport and energy-linked swelling. Inhibition of these processes, particularly K+ transport by low concentrations of local anesthetics, was most pronounced when histone, a basic protein, was employed to induce transport. Histones and local anesthetics may compete for an anionic binding site involved in K+ transport in mitochondria.
Footnotes
- Received November 27, 1968.
- Accepted March 1, 1969.
- © 1969 by The Williams & Wilkins Co.
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