Abstract
Microinjections of the cholinesterase inhibitor sarin were used to explore the pons and medulla of the rabbit. Bilateral injections into the lateral reticular nucleus of the medulla at the level of the inferior fovea caused respiratory arrest. Respiration was quickly restored after atropine was given i.v. Other effects observed, and reversed by i.v. atropine, included acceleration of respiratory rate, bradycardia and hypotension. The results are interpreted as indicating the location of a nervous center concerned with the control of the respiratory muscles, which is the site of the central respiratory paralysis in systemic sarin poisoning.
Footnotes
- Received June 10, 1966.
- Accepted March 29, 1968.
- © 1968 by The Williams & Wilkins Co.
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