Abstract
α-Naphthylisothiocyanate (ANIT) significantly enhanced the biliary bilirubin content as early as 2 hr after administration. The temporal aspects of this effect coincide with the development of hyperbilirubinemia after ANIT administration. The enhanced excretion of bilirubin is accompanied by an increase in the percentage incorporation of δ-aminolevulinic acid-14C into bilirubin, suggesting that one source of the ANIT-induced increase in bilirubin excretion may be nonerythropoietic in nature. Both the increase in bilirubin excretion and the incorporation of 14C into bilirubin are dose- and time-dependent.
Footnotes
- Received December 11, 1967.
- Accepted February 2, 1968.
- © 1968 by The Williams & Wilkins Company
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