Abstract
Cats injected with tracer amounts of S35 sodium sulfate were convulsed with strychnine for 5 min before sacrifice. Autoradiography combined with radioassay of 16 anatomical brain areas, muscle, nerve and liver revealed marked increases in S35 sulfate uptake, which were restricted to brain areas such as the lateral geniculate (316%), centrum medianum of thalamus (144%), cerebellar vermis (129%), medulla (207%) and cervical spinal cord (64%). The increase in the lateral geniculate was appreciably lese (221%) when the animal was blindfolded during the convulsion. Reversibility was indicated by return to normal S35 sulfate uptake within 1 hr after the 5-min seizure had been arrested with methocarbamol and trimethadione. The percentage of S35 sulfate metabolized in brain was reduced during a 5-min seizure. It was concluded that the localized increases in brain S35 sulfate levels reflected enhanced vascular-extravascular exchange at sites known to undergo activation or rhythmic discharge in response to strychnine administration.
Footnotes
- Received February 27, 1967.
- Accepted May 23, 1967.
- © 1967 by The Williams & Wilkins Company
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