Abstract
Pralidoxime chloride (2-PAM Cl) has been given orally to rats and the concentration of oxime in time blood plasma as well as time rate of elimination has been established. On the basis of a disappearance rate that approximated first-order kinetics the biologic half-life of the drug was estimated to be 1.4 hr. The prior administration of 2-PAM Cl to rats also treated with atropine resulted in significant decreases in the toxicity of sarin. These findings could be correlated with the concentration of oxime in the plasma at the time the toxicant was injected. The use in man of pralidoxime chloride in conjunction with atropine for the prophylaxis of poisoning by organophosphonis chemicals is suggested.
Footnotes
- Received February 10, 1967.
- Accepted March 17, 1967.
- © 1967 by The Williams & Wilkins Company
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In this issue
PROPHYLAXIS AGAINST SARIN POISONING IN THE RAT BY ORAL ADMINISTRATION OF PRALIDOXIME CHLORIDE
