Abstract
Eleven thiourea derivatives and their corresponding urea and thiosemicarbazide (TSC) analogues were tested for anticonvulsant properties. Compounds which had o-chlorobenzyl or o-methylbenzyl substitutions on one of the nitrogens had the greatest anticonvulsantpotency. The TSC derivatives may be divided into three groups, according to the relationship of activity and structure, as follows: 1) convulsant, with alkyl or allyl substitutions;2) anticonvulsant against maximal electroshock seizures, with substituted phenyl or benzyl groups; and 3) both anticonvulsant and convulsant, with simple or substituted phenyl or benzyl groups. None of the TSC derivatives was anticonvulsant against Metrazol, and all tended to exacerbate this clonic seizure pattern. The convulsions produced by TSC derivatives could be abolished or prevented by pyridoxal HCl. All TSC derivatives with antimaximal electroshock seizure activity, including those which also induced delayedseizures, caused a reduction in spontaneous motor activity.
Footnotes
- Received July 21, 1965.
- Accepted March 24, 1966.
- © 1966 by The Williams & Wilkins Co.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|