Abstract
Subcutaneous administration of several 19-nortestosterone derivatives produced an increased hepatic microsomal metabolism of hexobarbital and decreased zoxazolamine prostration time in mice. Testosterone and methyltestosterone produced an increased hexobarbital sleep time and testosterone decreased the rate of hepatic microsomal metabolism of hexobarbital. Although the ability of norethandrolone and SK & F 6612 (4-chloro-17α-methyl-19-nortestosterone) to shorten hexobarbital sleep time occurs within 6 to 12 hr after a single dose in mice, this effect of testosterone derivatives in rats occurs only after prolonged treatment.
Footnotes
- Accepted August 26, 1965.
- The Williams & Wilkins Comapny
Log in using your username and password
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
In this issue
THE INFLUENCE OF STEROIDS ON DRUG METABOLISM IN THE MOUSE
