Abstract
Circulating estradiol is selectively accumulated by the anterior pituitary, uterus, vagina, hypothalamus, septum and preoptic region. Pretreatment with the progestin norethynodrel reduced the H3-estradiol concentrations in the anterior pituitary, uterus, vagina, heart, adrenal, hypothalamus, preoptic region and septum. Treatment with norethynodrel after H3-estradiol administration reduced the radioactive concentration only in the uterus and vagina. Norethynodrel appeared to function as a competitive inhibitor of estradiol for binding. Evidence has been presented for an estradiol saturable binding mechanism in the anterior pituitary, uterus, vagina, and hypothalamus.
Footnotes
- Accepted July 23, 1965.
- The Williams & Wilkins Comapny
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