Abstract
The effect of epinephrine on rat skeletal muscle intracellular acid-base metabolism was studied by two independent methods of determining cell pH. A 30-minute i.v. infusion of epinephrine (2 µg/kg/min) was sufficient to cause a substantial extracellular metabolic acidosis, although this dose level had no effect on muscle intracellular acid-base parameters. No ready explanation for these observations is available at present. It thus appears that epinephrine cannot produce its other effects on skeletal muscle by a mechanism affecting either intracellular pH or bicarbonate concentration.
Footnotes
- Accepted May 26, 1965.
- The Williams & Wilkins Comapny
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.