Abstract
The effects of various adrenergic blocking agents on the cardiac positive inotropic action of epinephrine were studied in isolated perfused rabbit and turtle hearts. Some of the newer adrenergic blocking agents, including pronethalol (PRON), the N-isopropyl and n-butyl derivatives of p-nitrophenylethanolamine (INPEA and BNPEA, respectively) and N-isopropylmethoxamine (IMA) were compared with dichloroisoproterenol (DCI).
It was found that under the conditions of this study, all of these agents possess beta adrenergic receptor blocking activity in rabbit and turtle hearts. DCI and pronethalol were approximately equieffective and superior in their blocking ability to the other compounds tested. INPEA provided better blockade of the positive inotropic action of epinephrine than BNPEA and IMA, both of which possessed only weak beta blocking action.
Footnotes
- Accepted April 21, 1965.
- The Williams & Wilkins Comapny
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|