Abstract
A comparison has been made of the effect of the nerve sheath on the action of local anesthetics in three different types of nerve fiber preparations, namely, mammalian myelinated, mammalian nonmyelinated and amphibian myelinated nerve fibers.
In all types of fiber, alkaline anesthetic solutions were more effective in sheathed preparations, and neutral anesthetic solutions were more effective in desheathed preparations.
These results have confinned our earlier conclusion that the cation is the active form of local anesthetics and that the uncharged molecule is important only for penetration to the receptor site.
Footnotes
- Accepted May 7, 1965.
- The Williams & Wilkins Comapny
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.