Abstract
Enzymes are described that can metabolize monophenolic amines, N-acetylserotonin, estradiol, phenazocine and phenol to O-methylated dihydroxy derivatives. This reaction takes place in two steps, hydroxylation followed by O-methylation of the dihydroxy metabolite. These enzymes are localized in the liver microsomes and require NADPH for the formation of the dihydroxy compounds and S-adenosyl-methionine for the O-methylation reaction. Species and tissue distribution of the enzymes and the effects of some inhibitors are described.
Footnotes
- Accepted February 22, 1965.
- The Williams & Wilkins Comapny
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In this issue
ENZYMATIC FORMATION OF O-METHYLATED DIHYDROXY DERIVATIVES FROM PHENOLIC AMINES AND INDOLES
