Abstract
Ethacrynic acid reduces the concentration of stainable protein-bound sulfhydryl groups (PBSH) in renal cells of dogs at a time when diuresis is maximal or increasing. Neither a diuresis nor a reduction of PBSH occurs in rats even when the drug is administered intravenously in doses approximately 100 times as large as those effective in dogs.
The data indicate that ethacrynic acid occupies the same chemical "receptors" and may share the same mechanism of action as mercurial diuretics. If reaction of EA with PBSH leads to diuresis, then the site of action of the drug is more extensive than that of mercurials since it lowers PBSH of distal tubular cells as well as PBSH of proximal tubular and collecting duct cells; only the latter two types are influenced when mercurials are used.
Footnotes
- Accepted January 14, 1965.
- The Williams & Wilkins Comapny
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