Abstract
In a battery of tests, MA1337, a newly synthesized quinazolinedione derivative, was found to have central nervous system depressant activity at doses ranging from 0.06% to 1.9% of its acute LD50 in mice and rats. The dose-response curves of central depressant activity of MA1337 were flat. A blind cross-over behavioral observation in chronic dogs and cats for evaluation of central nervous system activity is described.
Footnotes
- Accepted January 6, 1965.
- The Williams & Wilkins Comapny
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