Abstract
The effects of morphine, pentobarbital and chlorpromazine upon the threshold voltage required to elicit a response to tooth pulp stimulation in the dog and the cat were quantitatively compared. In addition, a comparison was made of the variability among the animals to both the reaction to tooth pulp stimulation and the magnitude of drug effect.
All three of the compounds produced a greater elevation in tooth pulp thresholds than did saline in the dog. However, considerable variation existed among the dogs with respect to the magnitude of drug effect. In the cat, only morphine and chlorpromazine produced an elevation in tooth pulp thresholds significantly greater than saline. Chlorpromazine was found to be approximately one-half as potent as morphine in elevating tooth pulp thresholds in the cat. In addition, the variability among the cats in response to the drugs was less than in the dog.
It was concluded that a species difference exists between the dog and the cat with regard to both the response to tooth Pulp stimulation and the effect of drugs upon the reaction to tooth pulp stimulation.
Footnotes
- Accepted June 9, 1964.
- The Williams & Wilkins Comapny
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