Abstract
The movement of K42 between blood and the perfused CSF has been studied in anesthetized cats. Premedication with atropine did not affect the net movement of intravenously administered K42 from blood to perfusate. Addition of physostigmine or pilocarpine to the premedication decreased the net amount transferred whereas neostigmine had no significant effect. HC-3 increased the net amount of K42 reaching the perfusing CSF. These results implicate a cholinergic receptor in the transfer mechanism.
Pretreatment with acetazolamide, a number of digitalis glycosides and 2, 4-dinitrophenol all decreased the amount of K42 which reached the CSF.
When the K42 was added in varying concentrations to the perfusing CSF, the concentration in the perfused artificial CSF tended toward the normal value of 2.86 ± 0.26 mEq/l. This method also revealed evidence for an active component of potassium removal from ventricular CSF.
Footnotes
- Accepted February 12, 1964.
- The Williams & Wilkins Comapny
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