Abstract
Sustained elevated systolic and diastolic blood pressures were observed in dogs following the chronic daily oral administration of mecamylamine and chiorisondamine. The hypertension, once developed, was maintained despite substitution of the ganglionic blocking agent by a placebo. It could be lowered by the administration of hydrochlorothiazide, reserpine and phenoxybenzamine. Development of hypertension did not follow the chronic administration of hydrochlorothiazide or phenoxybenzamine. It is suggested that the effect may develop through a prolonged blockade of the sympathetic pathways believed to regulate mechanoreceptor sensitivity, resulting in "false" information being delivered to the central vasomotor areas and in a consequent readjustment in the mechanism regulating blood pressure.
Footnotes
- Received July 22, 1963.
- Accepted November 27, 1963.
- The Williams & Wilkins Company
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