Abstract
A double-blind factorial study has been carried out to determine the respiratory effects of morphine and caffeine in terms of the alveolar ventilation-end expiratory PCO2 response curve. Caffeine at the 500-mg dose level produced significant respiratory stimulation. When given in combination with 5 or 10 mg of morphine it produced significant reduction in the respiratory depression due to the narcotic. It appears that this is a surmountable, possibly a competitive, type antagonism and there is nothing to suggest that it is more than an additive effect between these two drugs.
Footnotes
- Received December 26, 1962.
- Accepted October 9, 1963.
- The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement