Abstract
A study of the relationship between the degree of edema, as estimated by a volume displacement method, and the intensity of hyperesthesia to pressure to the rat's paw inflamed by injection of graded doses of brewer's yeast indicates that whereas the inflammatory hyperesthesia and edema increase with increasing doses of yeast, the relationship between the phenomena is complex. Doses of aspirin which markedly reduced the intensity of hyperesthesia did not significantly reduce the degree of attendant edema. Reduction in foot volume manifested at the higher doses of the drug may have aided the process but was not essential to it.
Footnotes
- Received April 15, 1963.
- Accepted July 8, 1963.
- The Williams & Wilkins Company
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