Abstract
The inhibition of MAO by a series of benzyl and phenethylguanidines related to bretylium and guanethidine has been studied. The most potent inhibitor is N-o-chlorobenzyl-N'N''-dimethylguanidine (B.W. 392C60) which inhibits MAO in vitro to the same extent as phenylisopropylhydrazine (PIH, JB516). This compound has been shown to be a competitive and reversible inhibitor of MAO. The significance of this MAO inhibition in the mechanism of action of these hypotensive guanidines is discussed.
Footnotes
- Received March 11, 1963.
- Accepted May 1, 1963.
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