Abstract
The respiratory response of guinea pigs inhaling low concentrations of acrolein was characterized by an increase in total respiratory flow resistance, accompanied by decreased respiratory rates and increased tidal volumes. The magnitude of these effects increased with increasing acrolein concentrations studied, up to 1 ppm. The changes in respiratory function were reversible when the animals were returned to clean air. Atropine, aminophylline, isoproterenol and epinephrine partially or completely reversed the acrolein-induced increase in respiratory resistance, whereas tripelennamine and pyrilamine were without effect. The mechanism of increased resistance during acrolein-inhalation appears to be one of bronchoconstriction mediated through reflex cholinergic stimulation.
Footnotes
- Received February 27, 1963.
- Accepted April 10, 1963.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|