Abstract
The reactivity of the perfused dog hindquarters to several dilator and constrictor drugs was compared in normal and reserpine-pretreated animals. Responses to dilator agents and angiotensin were greater in normal innervated dogs than in reserpine-pretreated animals. Perfusion pressure was higher in the former group, however. After acute lumbar sympathectomy, perfusion pressures and responses to dilator agents and to angiotensin were not significantly different in the two groups. Constrictor responses to norepinephrine were greater in reserpine-pretreated dogs. Using maximal responses to acetylcholine and glyceryltrinitrate as an index of vascular tone, it was demonstrated that after sympathectomy approximately equal degrees of tone were present in both groups. It is concluded that reserpine-pretreatment does not depress the reactivity of the dog hindquarters preparation to the dilator agents used and that the cause of the reduced responses in pretreated dogs is the lowered perfusion pressure.
Footnotes
- Received January 21, 1963.
- Accepted March 27, 1963.
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