Abstract
(The numbers refer to the sections in the text)
1. The hemostatic effects of the thromboplastic agents tested on superficial hemorrhage from the dog's pad, although limited and variable, in general tend to agree with their power to accelerate coagulation of blood and plasma in vitro. Accordingly the thromboplastins and kephalin are among the most active; followed by saline and coagulen and hemostatic serum as either inactive or doubtful.
2. The extreme variability of results obtained after the application of various thromboplastic agents to dissected femoral arteries bleeding into Scarpa's triangles and the results from untreated vessels under similar conditions indicate that this method of testing these agents is unreliable and unsatisfactory. If anything, the results indicate the worthlessness of kephalin, coagulen, hemostatic serum and probably also the thromboplastins, as hemostatics under these conditions.
3. The application of various thromboplastic agents to bone and liver wounds of a dog gave unsatisfactory results. If anything, these were negative and do not support the claims that have been made for them.
4. Hemorrhage per se at intervals from arteries of dogs markedly (by 72 to 90 per cent) and promptly (ten to forty-seven minutes) shortens the coagulation time of blood, rendering it impossible to arrive at any definite conclusions concerning the thromboplastic activity of agents administered systemically.
5. The administration of 4 grams of kephalin by mouth to a patient with hemophilia and suffering with a troublesome intestinal hemorrhage was followed by prompt stoppage of the bleeding with shortening of the coagulation time and bleeding time of ear blood. This is not interpreted as $$Word$$ to kephalin, since bleeding in this patient was know and have stopped spontaneously before the treatment, illustrating the necessity of exercising the greatest care in interpreting data of this sort.
Footnotes
- Received July 24, 1919.
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