Abstract
The toxicity of ansphetamine sulfate in aggregated mice was found to increase with greater body weight, but remained relatively constant as the dose of amphetamine was increased from 15 to 60 mg/kg. An increase in the number of mice from 5 to 10 per cage (degree of aggregation) greatly increased the toxicity of amphetamine. Within a temperature range of 20° to 27.5°C each 2.5°C rise in temperature produced a significant increase in amphetamine toxicity. A significant interaction occurred between degree of aggregation and temperature. The size of the cage in which the mice were confined (degree of confinement) had little influence on the toxicity of amphetamine in mice grouped 10 per cage. A decrease in cage size augmented amphetamine toxicity in mice grouped 5 per cage.
Footnotes
- Received June 11, 1962.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|