Abstract
Paper chromatographic analysis of extracts of rat brain, followed by biological assay with the frog rectus preparation of the eluates of specific bands from the chromatograms, showed that the administration of either pentobarbital or ether to produce deep anesthesia in these animals, caused a significant increase of the acetylcholine activity in the brain. This increased acetylcholine activity was, perhaps, mainly due to the increased concentration of either one or several of the CoA ester derivatives of gamma-butyrobetaine, crotonbetaine and carnitine.
Footnotes
- Received July 3, 1961.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.