Abstract
The effect of chronic reserpine treatnmemmt on time sensitivity of the isolateol rabbit ileum to sympathomimetic agents has been investigated. Reserpine was found to increase the sensitivity of the ileum to the following catecholamines: epinephrine, norepinephrine and isoproterenol. The sensitivity to ephedrine was unchanged, while the sensitivity to tyramine was greatly reduced.
These results are discussed in relation to the mechanism of action of ephedrine anmd tyramine and in relation to time sensitivity of other organs to various sympathomimetics following denervation and reserpine pretreatment.
Footnotes
- Received June 12, 1961.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.