Abstract
Intraventricular administration of apomorphine hydrochloride (0.5 µg/kg) and of emetine hydrochloride (0.2 mg/kg) regularly evoked vomiting in dogs. Ablation of the medullary emetic chemoreceptor trigger zone (CT zone) rendered the dogs refractory to the emetic effect of these drugs injected intraventricularly. Ablation of the CT zone also prevented vomiting in response to intravenous emetine. The findings confirm the postulate of a direct action of apomorphine on the CT zone. They also suggest that emetine acts on the CT zone.
Footnotes
- Received May 24, 1961.
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