Abstract
Treatment of either intact or hypophysectomized rats with the antithyroid drugs, propylthiouracil, thiouracil and methimazole, is accompanied by an increased water intake and urinary output. The increased water intake does not appear to be the result of an increased "thirst" drive as assessed by drinking response either to dehydration or to Pitressin injection. It seems likely that the increased water intake observed is secondary to the increased urinary output since both intact and hypophysectomized rats, treated with propylthiouracil, manifest a decreased urinary concentrating ability after either dehydration or Pitressin administration. The latter may be due both to a reduced response of kidneys to endogenous antidiuretic hormone and to diuretic properties of the antithyroid drugs.
Footnotes
- Received January 17, 1961.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|