Abstract
Intravenous administration of neostigmine methylsulfate produced a pressor response in anesthetized animals following the administration of various competitive ganglionic blocking agents. This pressor response was not observed following the noncompetitive ganglionic blocking agent tetramethylammonium bromide.
The pressor response was antagonized by hemicholinium, bretylium, reserpine and various adrenolytic and anticholinergic agents.
When neostigmine was administered into the constantly perfused forelimb by arterial injection there was no vasoconstriction. Neostigmine administered intravenously produced constriction when the cervical chain had not been sectioned.
Neostigmine did not liberate pressor amines during perfusion of the isolated kidney amid adrenal gland.
Neostigmine given in the presence of ganglionic blockade produced myocardial and peripheral vascular responses similar to those seen with sympathetic nerve stimulation or administration of catecholamines.
The data from these experiments indicate that neostigmine acts at sympathetic ganglia.
Footnotes
- Received February 16, 1961.
- 1961 by The American Society for Pharmacology and Experimental Therapeutics
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