Abstract
The action of the mercurial diuretic, chlormerodrin, on the active sodium transport, the membrane potential and permeability to chloride of the isolated toad bladder was studied in an effort to determine whether the drug affected primarily the transport of sodium or chloride.
In concentrations of chlormerodrin 10-4 M or less, no significant effect was observed. In concentrations ranging from 1.25 to 1.5 x 10-4 M chlormerodrin, the sodium current and electrical potential were significantly depressed. Simultaneous measurements of the permeability of the membrane to chloride showed no significant change in the first 30 minutes, and then an increase in permeability. At no time was it decreased.
These findings are consistent with the hypothesis that mercurial diuretics diminish salt reabsorption in the mammalian renal tubule by a direct depression of active sodium transport and not by decreasing permeability to chloride.
Footnotes
- Received January 3, 1961.
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