Abstract
Two benzhydryl ether compounds, chlorphenoxamine and its diethyl analog, Keithon, were subjected to pharmacologic evaluation. By either the intraperitoneal or intragastric route, both compounds extended the normal sleeping time of hexobarbital in mice.
Anticonvulsant testing revealed that both drugs protected mice in the MES test and prevented the tonic extensor component of the maximal pentylenetetrazol test. Neither drug prevented the convulsions in mice resulting from the subcutaneous administration of pentylenetetrazol nor did they prevent the lethal effects of strychnine. Both drugs prevented the centrally induced convulsions in mice resulting from intravenous nicotine. They were found also to be antagonists of Tremorine-induced tremors in mice and reversed the analgetic effects when this agent was injected intramuscularly in mice.
In doses of 5 mg/kg intravenously, both chlorphenoxamine and Keithon either completely abolished or favorably altered the course of the jerking tic in clinical cases of the canine flexor spasm syndrome. The overall effect in this condition was the alteration of the tremor from a slow, coarse, disabling jerk to a faster but much less severe tremor.
Footnotes
- Received November 7, 1960.
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