Abstract
The details of the preparation of radiochemically pure tritium nuclear-labeled morphine are described. Twenty-four per cent of the dose of morphine-H3 administered to male Sprague-Dawley rats was recovered as urinary free morphine and 14% as conjugated morphine. Approximately 74% of the administered radioactivity was recovered in the rat urine.
Evidence from paper chromatographic experiments has been obtained for the in vivo biotransformation of morphine to normorphine by the rat, some of the normorphine appearing as a conjugate.
Footnotes
- Received November 21, 1960.
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