Abstract
The relative antitussive efficacies of alpha (dimethylaminoethyl)-ortho-chlorobenzhydrol hydrochloride (SL-501, Bayer B-186), codeine, dihydrocodeinone and several currently used nonnarcotic antitussives have been appraised by a method in which experimental cough was induced by aerosolized N sulfuric acid in unanesthetized dogs. SL-501, a new nonnarcotic antitussive, shows a potent and long-acting cough-suppressing activity in dogs. It has a relatively slower onset of maximum action than the narcotics.
SL-501 exhibits moderate local anesthetic effects and a mild antispasmodic action. It also causes some prolongation of sleeping time in pentobarbitalized mice. No analgesic, sedative-hypnotic, antihistaminic or antiemetic properties were demonstrated.
Acute and chronic toxicity studies in animals indicate that SL-501 is relatively nontoxic, and has a high therapeutic ratio.
Footnotes
- Received September 24, 1959.
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