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Research ArticleArticle

AMINO-METHYLCHROMONES, BRAIN STEM STIMULANTS AND PENTOBARBITAL ANTAGONISTS

I. Setnikar, W. Murmann, M. J. Magistretti and P. Da Re
Journal of Pharmacology and Experimental Therapeutics February 1960, 128 (2) 176-181;
I. Setnikar
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W. Murmann
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M. J. Magistretti
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P. Da Re
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Abstract

The CNS stimulant activity of two new brain stem stimulants, 2,3-dimethyl-7-methoxy-morpholinomethylchromone hydrochloride (Rec 7- 0105) and 3-methyl-7-methoxy-8-dimethylamino-methylflavone hydrochloride (Rec 7-0267, dimefline) are compared with other brain stem stimulants of known efficacy and with other CNS stimulants. The capacity of all the drugs under examination for antagonizing the toxic effects of pentobarbital is described. Only brain stem stimulants are capable of exerting a true antagonism to this barbiturate. The two new drugs are more active thanbemegride, picrotoxin and Metrazol.

Footnotes

    • Received July 20, 1959.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 128, Issue 2
1 Feb 1960
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Research ArticleArticle

AMINO-METHYLCHROMONES, BRAIN STEM STIMULANTS AND PENTOBARBITAL ANTAGONISTS

I. Setnikar, W. Murmann, M. J. Magistretti and P. Da Re
Journal of Pharmacology and Experimental Therapeutics February 1, 1960, 128 (2) 176-181;

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Research ArticleArticle

AMINO-METHYLCHROMONES, BRAIN STEM STIMULANTS AND PENTOBARBITAL ANTAGONISTS

I. Setnikar, W. Murmann, M. J. Magistretti and P. Da Re
Journal of Pharmacology and Experimental Therapeutics February 1, 1960, 128 (2) 176-181;
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