Abstract
By means of paper chromatography and comparison with known compounds, the urinary metabolites of salicylamide in stone-forming patients were investigated. Twelve selected cases, among a larger group, in which the dose of salicylamide was 2.0 to 3.6 g daily are reported. It was indicated that 46% of the salicylamide was excreted as glucuronide and 31% as the sulfate on the average. Also, free salicylamide appeared in 50% of the cases and salicyluric acid in 40% in undetermined amounts.
In general, the salicylamide glucuronide excreted was the ether, but a small amount of ester glucuronide was determined in patients with high glucuronide outputs. This was determined by differential hydrolyses.
Footnotes
- Received September 19, 1958.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.