Abstract
Two metabolites of phenylbutazone which were isolated from human urine possess some of the pharmacological activities of the parent drug. Metabolite I, formed by the introduction of a phenolic group in a benzene ring, has the potent antirheumatic and sodium-retaining effects of phenylbutazone. Metabolite II, formed by the introduction of an alcohol group in the butyl side chain, possesses reduced sodium-retaining and antirheumatic properties, but it is a considerably more potent uricosuric agent than phenylbutazone.
Footnotes
- Received December 23, 1957.
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