Abstract
Both chlorpromazine and reserpine inhibited the response of the rat to acute stress as measured by the degree of adrenal ascorbic acid depletion. Reserpine was extraordinarily effective in blocking activation in the low doses used. Neither drug prevented the adrenal ascorbic acid depleting action of exogeneous ACTH. The possible mechanisms of action of chlorpromazine and reserpine are discussed. Our results, supported by the results of other authors with chlorpromazine, are suggestive of an action on the prepituitary phase of response to stress, possibly on the hypothalamus.
Footnotes
- Received January 23, 1958.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.