Abstract
The complex of antihypertensive activities exhibited by methylphenidate is explained only in part by effects elicited in the efferent periphery. The blocking effect of methylphenidate on amphetamine hypertension has a distinct efferent peripheral component. The antagonizing effect of methylphenidate on carotid occlusion reflex pressor responses cannot be explained by an obvious afferent or efferent peripheral blockade. The moderate antihypertensive effect of methylphenidate in the renal hypertensive dog cannot be explained by a blocking effect on the rerin pressor system.
Footnotes
- Received January 29, 1958.
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