Abstract
The anticholinesterase activity of four bis α, α'-disubstituted-4 , 4'biacetanilids has been evaluated. The experimental procedures included intravenous toxicity, duration of action, in vitro cholinesterase inhibition, effects on dog blood pressure, d-tubocurarine antagonism, and acetylcholine potentiation on the isolated rabbit heart. The 2-methylpyridyl and 3-methylpyridyl disubstitution derivatives were found to be more active than neostigmine on a molar basis. Correlations of position isomerism on the heterocyclic quaternary cationic head of the molecule with anticholinesterase activity have been discussed.
Footnotes
- Received May 2, 1957.
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