Abstract
The convulsant properties of NH4Ac, strychnine, picrotoxin, Metrazol, Coramine, and caffeine have been investigated by timed intravenous infusion in mice. Data on seizure patterns and on antagonism with various anticonvulsant agents under the influence of reserpine are presented to show how the convulsant effects of these agents may be clearly distinguished from one another by the difference in clonic and tonic-extensor seizure responses.
In strychnine-, Metrazol- and caffeine-induced convulsive seizures, a comparative study was made of the anticonvulsant effects of Dilantin, phenobarbital, barbital, Milontin, PM 396, Phenurone, carbromal, Tolserol, and sodium bromide. The results are elucidated from the standpoint of a Dilantin-type, mephenesin-type or barbital-type anticonvulsant effect.
Reserpine was found to have a suppressive effect on strychnine-induced tonic-extensor seizures and on Metrazol-induced clonic seizures in mice. This depressant action of reserpine was more pronounced when investigated jointly with barbital.
Footnotes
- Received December 27, 1955.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|