Abstract
Nalorphine hydrochloride administered subcutaneously in a dose of 10 mgm./ kgm. to rats tolerant to 100 mgm./kgm. of morphine sulfate, administered subcutaneously twice daily, induces an "abstinence syndrome". The signs of this "abstinence syndrome" in the rat are sedation, loss of both muscular rigidity and exophthalmos and a marked increase in intestinal activity as evidenced by increased defecation, soft stools, and occasional diarrhea. A low grade tolerance is developed by the rat to 100 mgm./kgm. of nalorphine hydrochloride, administered twice daily.
Footnotes
- Received January 3, 1956.
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