Abstract
Marsilid, a compound almost devoid of sedative action, prolongs the hypnotic activity of hexobarbital in mice by interference with the rate of its metabolic transformation.
Marsilid inhibits oxidative enzyme systems in liver microsomes which oxidize the side chain of hexobarbital, dealkylate aminopyrine, deaminate amphetamine, and hydroxylate acetanilide. The biotransformation of these drugs is also inhibited by β-diethylaminoethyl diphenylpropylacetate (SKF 525-A) and 2,4-dichloro-6-phenylphenoxyethyl diethylamine (Lilly 18947).
The mechanism of inhibition of drug metabolisms by Marsilid is, like that of SKF 525-A and Lilly 18947, unknown. It is presumably not due to an interchange of Marsilid with the nicotinamide moiety of the pyridine nucleotides DPN or TPN. Despite their dissimilarity in structure, Marsilid, Lilly 18947, and SKF 525-A probably act by a similar mechanism.
Footnotes
- Received November 21, 1955.
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ON THE MECHANISM OF DRUG POTENTIATION BY IPRONIAZID (2-ISOPROPYL-1-ISONICOTINYL HYDRAZINE)
