Abstract
The cardio-active urinary excretory products of lanatoside C and digitoxin in rat urine have been studied by the use of paper chromatography and estimated quantitatively by the embryonic chick heart method.
Unchanged lanatoside C is excreted in the first 24 hours to the extent of about 7.5 per cent of the administered dose (1 microgm./gm. of body weight). When larger doses are given, free digoxin and a cardio-active metabolite previously found in rat urine after digoxin administration also appear.
Very little unchanged digitoxin is excreted in rat urine, but a metabolite which is not digitoxigenin, but which apparently has lower biological activity than digitoxin is present in the first 24 hours' urine excretion.
Footnotes
- Received December 3, 1954.
- © 1955, by The Williams & Wilkins Company