Abstract
The cardio-active urinary excretion products in rat urine after digoxin administration have been studied by paper chromatography and measured quantitatively by the embryonic chick heart method.
Approximately 10 per cent of the dose of digoxin is excreted in the first 24 hours in the form of active metabolites.
A cardio-active metabolite of digoxin which is not digoxigenin but which retains the unsaturated lactone ring has been detected in rat urine.
Footnotes
- Received May 11, 1954.
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