Abstract
β-Diethylaminoethyl diphenylpropylacetate HCl (SKF 525-A) inhibits the enzyme systems in liver slices and homogenates which oxidize the sidechains of pentobarbital, secobarbital, and hexobarbital; dealkylate meperidine, Dibenamine, aminopyrine and its diethyl analogue; deaminate amphetamine; cleave the ether linkage in codeine; and conjugate morphine.
Diphenylpropylacetic acid, a hydrolytic product of SKF 525-A is equally active at a cellular level, though less active in the intact animal.
It is concluded that SKF 525-A inhibits a factor or factors that a diversity of drug enzyme systems possess in common.
Footnotes
- Received April 19, 1954.
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