Abstract
The antidiuretic effect of morphine is effectively blocked by nalorphine. Nalorphine by itself has neither a diuretic nor an antidiuretic action, nor does it antagonize the antidiuretic effect of vasopressin.
The urine of morphinized rats contains an antidiuretic substance which is not morphine, and which is not antagonized by nalorphine. The urine of rats given both morphine and nalorphine does not contain this substance.
The evidence suggests that morphine stimulates the release of antidiuretic hormone from the posterior lobe of the pituitary, and that nalorphine blocks this action of morphine. The site of action is considered to be the hypothalamus.
Footnotes
- Received March 25, 1954.
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