Abstract
Partial hepatectomy in the rat results in a large decrease in the rate of demethylation of l-Mesantoin and of trimethadione.
It is concluded that the liver is the principal, if not the only, site of the demethylation of these drugs.
The suggestion is made that the liver is probably the principal site of demethylation not only of N-methyl derivatives of barbituric acid, hydantoin, and 2,4-oxazolidinedione but also of analogous compounds of other chemical types.
Footnotes
- Received October 5, 1953.
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THE ROLE OF THE LIVER IN THE DEMETHYLATION OF N-METHYL DERIVATIVES OF HYDANTOIN AND OF 2,4-OXAZOLIDINEDIONE
