Abstract
An appraisal of the anticonvulsant activity has been made of derivatives of α-phenyl succinimide. The α,β-methyl and ethyl substituted compounds were more effective against Metrazol than against electrically-induced convulsions. Methylation of the heterocyclic nitrogen of most of these succinimides resulted in an increase in anti-Metrazol potency. This enhancing effect becomes less with the increasing length and branching of the alkyl chain.
The α,α-diphenyl and the α,β-diphenyl succinimides on the other hand, were more effective in suppressing electrically-induced than Metrazol-induced convulsions. Methylation of the heterocyclic nitrogen of these compounds diminished their anti-electroshock activity.
Footnotes
- Received June 11, 1951.
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