Abstract
1. Aurin tricarboxylic acid, given intravenously in the form of the ammonium salt, markedly increased the survival of mice given an intravenous LD95 of beryllium sulfate (0.7 mgm. Be per kgm.).
2. Rats acutely poisoned with Be were similarly protected.
3. ATA was effective when administered from one hour before to at least eight hours after the injection of Be, and in doses from 1 to 4 mgm. per mouse. Partial protection was given when it was administered 52 hours prior to Be, but none when given sixteen hours after Be.
4. Partial protection was afforded mice given up to 1.0 mgm. of Be per kgm.
5. Repeated small doses of aurin tricarboxylic acid, begun one hour after Be injection and continued at one- or two-day intervals, did not increase survival in mice. Oral administration of a 0.5 per cent solution in drinking water was also ineffective.
Footnotes
- Received February 8, 1951.
Log in using your username and password
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$25.00
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
In this issue
PROTECTION AGAINST EXPERIMENTAL BERYLLIUM POISONING BY AURIN TRICARBOXYLIC ACID
