Abstract
The administration of physostigmine to mice prior to intravenous injection of either barbital or glucochloralose has been found to reduce the anesthetic lag by about 50 per cent. In the case of barbital, this is accompanied by an increase in the rate of penetration of the drug into the brain.
This increased permeability of the brain to the anesthetic is attributed to inhibition of cholinesterase activity by physostigmine.
Footnotes
- Received December 18, 1950.
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